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Cellular Physiology and Biochemistry (2018-08-01) . Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function

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T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). - Mechanism of Action & Protocol.

Inhibering av ANOl med CaCCinh-A01, T16Ainh-A01 eller Ani9 minskar levande celltal på en dosberoende eller tidsberoende sätt. d-f stapeldiagram som visar  bröstcancer [30, 34], och farmakologisk hämning av CACC ANO1 aktivitet genom CaCCinh-A01 och T16Ainh-A01 kan hämma cancercelltillväxt [32, 35, 36]. 552309-42-9. T16AInh-A01. T16Ainh - A01. t16a(inh)-a01. 2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current.

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CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). For research use only. We do not sell to patients. T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2 T16Ainh-A01 is a potent inhibitor of transmembrane protein 16A (TMEM16A), inhibiting TMEM16A-mediated chloride currents (IC50 of ~1 µM),and functions as a calcium-activated chloride channel (CaCC). The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications.

Structure, properties, spectra, suppliers and links for: t16ainh-a01, 552309-42-9.

T16Ainh - A01 is a Ca 2+ -activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Buy Calcium Channel inhibitor T16Ainh - A01 from AbMole BioScience.

T16ainh-a01

The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+.

T16ainh-a01

Welcome About BGC Terms of Use MSDS Banner Adverts  EINECS. Formel. T16Ainh - A01. 552309-42-9. C19H20N4O3S2. Tmem16ainhibitorsrevealtmem16a(t16ainh-a01).

T16ainh-a01

MONNA and T16Ainh -A01 also increased coronary flow in Langendorff perfused rat heart preparations. TMEM16A mRNA was increased in coronary artery smooth muscle cells from SHRs, and U46619 and 5-HT were more potent in arteries from SHRs than in those from normal Wistar rats. Figure 4: Intrathecal injection of the selective TMEM16A inhibitor T16Ainh-A01 attenuates CCI-induced hyperalgesia. Time course of the antiallodynic effect of T16Ainh-A01 (10 μg) in rats subjected to CCI. Withdrawal threshold was assessed 14 days after CCI. Data are expressed as the mean ± SEM (n = 6 per group). #P < 0.05, ###P < 0.001, vs.
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Epithelial cells from guinea-pig tracheas were cultured at the air-liquid interface in the presence of IL-13 for in vitro study. In contrast, spontaneous Ca2+ waves in isolated RUICC were only partially reduced by CACCinh-A01 and T16Ainh-A01.

TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). - Mechanism of Action & Protocol. Background and Purpose T16Ainh‐A01 is a recently identified inhibitor of the calcium‐activated chloride channel TMEM16A.
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The voltage-dependent component disappears due to VGCC inhibition, suggesting that Ca2+ is the essential trigger for ANO1. In perforated current-clamping method, the application of T16Ainh-A01 and reduction of Cl− extended excitation periods in rod bipolar cells, revealing that ANO1 induces repolarization during excitation.

T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of Quality confirmed by NMR & HPLC. TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem TMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). - Find MSDS or SDS, a COA, data sheets and more information.